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Welcome to Wilkes University » Faculty and Staff
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Faculty and Staff

Contact

Office: Cohen Science Center

Room: 209

Phone: 5704084361

Email: christian.laing@wilkes.edu

Dr. Christian E. Laing

Assistant Professor

Biology

Biography

 

View Dr. Laing's Website

EDUCATION

New York University, New York, NY
Postdoctoral research (Computational Biology) April 2007 - May 2011

Florida State University, Tallahassee, FL
PhD Biomedical Mathematics (Computational Biology), thesis "Biomedical applications of shape descriptors"
PhD Advisor: De Witt Sumners, March 2007
Master of Science in Biomedical Mathematics (Computational Biology), May 2003

Universidad de Guanajuato, Guanajuato, Gto, México
Bachelor of Science in Mathematics. Thesis title "El Grupo Fundamental para Enlaces"
Advisor: Jose Carlos Gomez Larrañaga, May 2001

RESEARCH INTERESTS

  • Topology and Differential Geometry
  • Computational Biology
  • DNA topology
  • RNA folding
  • RNA structural genomics and 3D motifs
     

SELECTED PUBLICATIONS

Christian Laing, Dongron Wen, Jason T. L. Wang and Tamar Schlick. Predicting Coaxial Helical Stacking in RNA Junctions. doi: 10.1093/nar/gkr629 (2011)

Christian Laing and Tamar Schlick. Computational Approaches to RNA Structure Prediction, Analysis and Design. 21:1-13 Current Opinion in Structural Biology (2011)

Christian Laing and Tamar Schlick. Computational Approaches to 3D Modeling of RNA. 22:283101 Journal of Physics: Condensed Matter (2010)

Christian Laing, Segun Jung, Abdul Iqbal and Tamar Schlick. Tertiary Motifs Revealed in Analyses of Higher Order RNA Junctions. 393(1):67-82 Journal of Molecular Biology (2009)

Christian Laing and Tamar Schlick. Analysis of Four-Way Junctions in RNA Structures. 390(3):547-559 Journal of Molecular Biology (2009)

Monica K. Hurdal, Juan B. Gutierrez, Christian Laing, Aaron D. Kline and Deborah A. Smith. Geometric Invariants for Classification of Cortical Sulci. Image Processing, ICIP, 15th IEEE International Conference on Imaging Processing 1156-1159 (2008)

Christian Laing and De Witt Sumners. The Writhe of Oriented Polygonal Graphs. Journal of Knot Theory and its Ramifications; 17(12):1575-1594 (2008)

Yurong Xin, Christian Laing, Neocles B. Leontis and Tamar Schlick. Annotation of Tertiary Interactions in RNA Structures Reveals Variations and Correlations. RNA; 14:2465-2477 (2008)

Monica K. Hurdal, Juan B. Gutierrez, Christian Laing and Deborah A. Smith. Shape Analysis for Automated Sulcal Classification and Parcellation of MRI Data. Journal of Combinatorial Optimization, 15(3):257-275. Springer Netherlands (2008)

Trevor Blackstone, Paul McGuirck, Christian Laing, Mariel Vazquez, Joaquin Roca and Javier Arsuaga. The Role of Writhe in DNA Condensation. Proceedings of International Workshop on Knot Theory for Scientific Objects. OCAMI Studies Volume 1 (2) Osaka Municipal Universities Press; 239-250 (2007)

Christian Laing and De Witt Sumners. Computing the Writhe on Lattices. Journal of Physics A: Mathematics and General. 39:1-9 (2006)
 

RESEARCH PROJECT

RNA tertiary structure analysis and prediction

RNA folding is recognized as hierarchical. An RNA sequence forms secondary structural elements (helices and single strands), followed by recurrent tertiary interactions, and then it folds into a native structure. RNA tertiary motifs are recurrent interactions connecting between secondary structural elements. Understanding the role of RNA tertiary motifs in RNA folding will help to understand RNA 3D prediction.

AWARDS

2008: The Mexican Educational Foundation of New York, New York City, NY. Recognition for mentoring in Science and Mathematics at the Washington Irving High School of New York City

2005: Florida State University, Tallahassee, FL. Program in Mathematics and Molecular Biology (PMMB) Fellowship

2004: Howard Hughes Fellowship

2002-2007: Recipient of the FSU Latin American - Caribean (LAC) Scholarship

1998-2001: Universidad de Guanajuato CIMAT, Guanajuato, Mexico. CIMAT Undergraduate Fellowship

2000: Summer Research Fellowship, Primer Verano de la Investigacion del Centro

 

 

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