Wilkes University

Biochemistry

Biochemistry Major

The Biochemistry curriculum is designed to provide comprehensive background education and training for students interested in the chemistry of physiological systems. The B.S. curriculum meets the liberal arts requirements of the University with a concentration in advanced courses. It was developed for those students who wish to prepare for Biochemistry as a professional option. Holders of this degree seek employment directly in the field or they can pursue advanced degrees in graduate or professional schools.

The Biochemistry degree was developed for those students interested in Biochemistry as a means of preparation for entrance into health science professional schools such as allopathic, osteopathic, and podiatric medicine, dental medicine, optometry, etc. Two specific features of the program are that students (1) may pursue the first three years of the Biochemistry degree curriculum in the three-year option under one of the Wilkes University combined seven-year medical and baccalaureate degree programs or (2) use the seventh or eighth semesters in cooperative research programs. The latter option is particularly useful for those students selected to The Premedical Scholars Program (see Affiliated Degree Programs in Medicine).

The Wilkes Chemistry and Biochemistry programs are approved by the American Chemical Society for the professional training of chemists.  Students who complete either of these B.S. programs are certified for membership eligibility in the Society at graduation. Students completing the B.A. program in Chemistry may be certified, dependent upon the student's choice of chemistry courses.

Biochemistry Major - Required Courses and Recommended Course Sequence

 

First Semester Credits

CHM-113 - Elements & Compounds Lab

1

CHM-115 - Elements & Compounds

3

BIO-121 - Princ. of Modern Biology I

4

MTH-111 - Calculus I

4

FYF-101 - First-Year Foundations

3

 

15

Second Semester

CHM-114 - The Chem. Reaction Lab

1

CHM-116 - The Chemical Reaction

3

BIO-122 - Princ. of Modern Biology II

4

MTH-112 - Calculus II

4

ENG-101 - Composition

4

 

16

Third Semester

CHM-231 - Organic Chemistry I

3

CHM-233 - Organic Chem. I Lab

1

PHY-201 - General Physics I

3

PHY-203 - General Physics I Lab

1

CS-125 - Computer Science I

4

Distribution Requirements

6

 

18

Fourth Semester

CHM-232 - Organic Chemistry II

3

CHM-234 -  Organic Chem. II Lab

1

PHY-202 - General Physics II

3

PHY-204 - General Physics II Lab

1

MTH-212 - Multivariable Calculus

4

CHM-248 - Analytical Chemistry

3

CHM-246 - Analytical Chemistry Lab

1

 

16

Fifth Semester

CHM-351 - Physical Chemistry: Quantum & Spectro

3

CHM-353 - Physical Chem: Quantum & Spectro Lab

1

CHM-361 - Biochemistry I

3

CHM-363 - Biochemistry Lab*

1

Distribution Requirement

3

CHM-341 - Instrumental Analysis

3

CHM-343 - Instrumental Analysis Lab

1

 

15

Sixth Semester

CHM-352 - Physical Chemistry: Kinetics & Thermo

3

CHM-354 - Physical Chem: Kinetics & Thermo Lab

1

CHM-362 - Biochemistry II

3

CHM-390 - Junior Seminar

1

BIO-226 - Cellular and Molecular Biology

4

Distribution Requirement

3

 

15

Seventh Semester

CHM-391 - Senior Research I

2

CHM-371 Integrated Laboratory*

1

Major Elective**

3-4

Distribution Requirement

6

Free Elective

3

 

15-16

Eighth Semester

CHM-322 - Inorganic Chemistry

3

CHM-323 - Inorganic Laboratory*

1

CHM-392 - Senior Research II

2

Major Elective**

3-4

Free Elective

3

 

12-13

*All biochemistry majors are required to take the Biochemistry Laboratory (CHM 363) plus two (2) credits total of Inorganic Laboratory (CHM 323) and/or Integrated Laboratory (CHM 370, 371, 372).
** All biochemistry majors are required to take a total of 2 major electives (6-8 credits) chosen from BIO-324, BIO-326, BIO-327, BIO-329, BIO-330, BIO-345, PHY-377 or an approved CHM-398 topics course.


Chemistry

CHM-105. Chemistry and Modern Society

Credits: 3

This course will emphasize consumer applications of chemistry with some emphasis on environmental consequences of the use of various forms of energy (nuclear, coal, petroleum, natural gas) and everyday chemicals (foods, drugs, agricultural chemicals, and chemicals used in pest control). 

CHM-111. Fundamentals of Chemistry

Credits: 4

Designed for students who do not intend to major in science or engineering, this one-semester course presents principles of chemistry. Topics include atomic structure, chemical bonding, gas laws, solutions, acid/base chemistry and an introduction to organic and biochemistry. A laboratory component is required as part of this course, in which students will develop basic principles of laboratory technique. Students may not receive credit for both CHM 111 and CHM 113/115. Three hours of class, one hour of problem session, and two hours of lab per week.

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Pre-Requisites
Departmental placement criteria are met.

CHM-113. Elements and Compounds Lab

Credits: 1

This is the first chemistry laboratory course in the two-semester general chemistry sequence. Experiments are performed to reinforce the concepts learned in CHM-115. One three-hour laboratory per week.

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Pre-Requisites
Departmental placement criteria are met
Co-Requisites

CHM-114. The Chemical Reaction Lab

Credits: 1

This is the second chemistry laboratory course in the two-semester general chemistry sequence. Experiments are performed to reinforce the concepts learned in CHM-116. One three-hour laboratory per week.


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Pre-Requisites
CHM-113 with a grade of 2.0 or better and CHM-115 with a grade of 2.0 or better
Co-Requisites

CHM-115. Elements and Compounds

Credits: 3

Emphasis is placed on the periodic table and stoichiometry, including chemical properties, physical states, and structure. Three hours of class and a one-hour problem session per week.
Corequisite: CHM-113.

Pre-Requisites

Departmental placement criteria are met.

CHM-116. The Chemical Reaction

Credits: 3

A detailed study of chemical equilibria in aqueous solution. Three hours of class and a one-hour problem session per week.

Pre-Requisites
CHM-113 with a grade of 2.0 or better and CHM-115 with a grade of 2.0 or better
Co-Requisites

CHM-117. Introductory Chemistry Lab for Engineers

Credits: 1

This is a one-semester introductory chemistry laboratory course for engineering students. Experiments are performed to reinforce the concepts learned in CHM-118. One three-hour lab per week.

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Pre-Requisites
Departmental placement criteria are met.
Co-Requisites

CHM-118. Chemistry for Engineers

Credits: 3

This course covers the foundations of chemistry, matter and measurements, periodicity, atomic and molecular structure, stoichiometry, states of matter, phase changes, kinetics, equilibrium, thermochemistry and electrochemistry.  Four hours of lecture per week.

Pre-Requisites
Departmental placement criteria are met
Co-Requisites

CHM-231. Organic Chemistry I

Credits: 3
Terms Offered: Summer

An introduction to the chemistry of carbon compounds, this course develops the interconnected relationship between bonding, structure, properties and reactivity in organic compounds. Instrumental methods will be presented as a means to determine structure. Three hours of class and a one-hour problem session per week.

Pre-Requisites
CHM-114 with a grade of 2.0 or better and CHM-116 with a grade of 2.0 or better
Co-Requisites

CHM-232. Organic Chemistry II

Credits: 3

This course continues CHM-231, with emphasis on organic synthesis. Three hours of class and a one-hour problem session per week.

Pre-Requisites
CHM-231 with a grade of 2.0 or better and CHM-233 with a grade of 2.0 or better
Co-Requisites

CHM-233. Organic Chemistry I Lab

Credits: 1

After an introduction to standard organic reaction, purification, physical characterization, and spectroscopic techniques, students will investigate concepts discussed in CHM-231. One three-hour laboratory per week.

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Pre-Requisites

CHM-114 with a grade of 2.0 or better and CHM-116 with a grade of 2.0 or better

Co-Requisites

CHM-234. Organic Chemistry II Lab

Credits: 1

Weekly labs that parallel the lecture topics in CHM-232 and emphasize organic synthesis and characterization, including multistep synthesis. Three hours per week.

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Pre-Requisites
CHM-231 with a grade of 2.0 or better and CHM-233 with a grade of 2.0 or better
Co-Requisites

CHM-235. Essentials of Organic Chemistry

Credits: 3

A one semester course covering the fundamentals of carbon chemistry. Nomenclature, stereochemistry, functional groups, spectroscopy, and reactions and mechanisms of alcohols, ethers, amines, alkyl halides, carbonyl compounds, and benzene are covered. Four hours of lecture per week.




Pre-Requisites
CHM-114 with a grade of 2.0 or better and CHM-116 with a grade of 2.0 or better.
Co-Requisites

CHM-237. Essentials of Organic Chemistry Lab

Credits: 1

A one semester fundamental organic chemistry laboratory course that introduces organic reactions, purification, physical characterization and spectroscopic techniques.


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Pre-Requisites
CHM-114 with a grade of 2.0 or better and CHM-116 with a grade of 2.0 or better.
Co-Requisites

CHM-246. Analytical Chemistry Lab

Credits: 1

Weekly labs that parallel the lecture topics in CHM-248. One three-hour laboratory per week. 


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Pre-Requisites

CHM-114 with a grade of 2.0 or better and CHM-116 with a grade of 2.0 or better 

Co-Requisites

CHM-248. Analytical Chemistry

Credits: 3

A course in the application of the principles of chemical equilibria to obtain the qualitative and quantitative information about the composition and structure of matter. An introduction to the importance of sampling is included along with methods for the statistical treatment of data. The course focuses primarily on the analyses of elemental and ionic species using electrochemical, spectroscopic, and chromatographic techniques.  Three hours of lecture per week.

Pre-Requisites
CHM-114 with a grade of 2.0 or better and CHM-116 with a grade of 2.0 or better
Co-Requisites

CHM-256. Polymer Chemistry

Credits: 3

This course covers topics in polymer composition and structure, polymerization mechanisms, stereochemistry of polymerization and reaction of polymers. Three hours of lecture per week.

Pre-Requisites
CHM-117 with a grade of 2.0 or better and CHM-118 with a grade of 2.0 or better

CHM-258. Polymer Chemistry Laboratory

Credits: 1

Experiments are conducted to emphasize the concepts learned in the Polymer Chemistry lecture course, CHM-256.  Students will collect and process experimental data and develop laboratory skills. One three-hour laboratory per week.

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Pre-Requisites
Co-Requisites

CHM-322. Inorganic Chemistry

Credits: 3

CHM-322 presents a survey of current topics in Inorganic Chemistry. The first half of the course offers a survey of main group chemistry, including individual group trends. The second half of the course covers Crystal Field Theory, Ligand Field Theory, reaction mechanisms, and organometallic compounds. Three hours of lecture per week.

Pre-Requisites
CHM-114 with a grade of 2.0 or better &  CHM-116 with a grade of 2.0 or better

CHM-323. Advanced Inorganic ChemistryLab

Credits: 1

Advanced Inorganic Chemistry Laboratory is the complimentary laboratory to CHM-322 Inorganic Chemistry. Students will build upon the foundational concepts first explored in CHM-322. An emphasis will be placed on the synthesis and characterization of transition metal complexes. Coordination chemistry reactions and mechanisms will be introduced as well as the chemistry of lanthanides. Students will gain experience in the handling of air-sensitive materials. Laboratory, three hours per week.

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Pre-Requisites

CHM-341. Instrumental Methods for Chemical Analysis

Credits: 3

A course in the fundamental principles that provide the basis for the design and fabrication of chemical instrumentation. The underlying physical basis for each method is introduced through an exploration of the capabilities, limitations, and applications of a wide range of separations, spectroscopic, and electrochemical methods. Three hours of lecture per week.

Pre-Requisites
CHM-246 with a grade of 2.0 or better, CHM-248 with a grade of 2.0 or better, MTH-112, PHY-202
Co-Requisites

CHM-343. Instrumental Methods for Chemical Analysis Lab

Credits: 1

Weekly lab that corresponds to the lecture topics in CHM-341. One three-hour laboratory per week.

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Co-Requisites

CHM-351. Physical Chemistry: Quantum and Spectroscopy

Credits: 3

This course emphasizes the molecular approach to physical chemistry. It begins discussing the principles of quantum mechanics and their applications in chemistry, leading to atomic and molecular structure, and chemical bonding. These concepts are then used in the development of atomic and molecular spectroscopy. Photochemistry is introduced. Three hours of lecture per week.

Pre-Requisites
CHM-114 with a grade of 2.0 or better, CHM-116 with a grade of 2.0 or better, MTH-212 and PHY-202

CHM-352. Physical Chemistry: Kinetics and Thermodynamics

Credits: 3

Statistical mechanics is used to formulate thermodynamics in terms of atomic and molecular properties, allowing a molecular interpretation of the laws of thermodynamics. Three hours of lecture a week.

Pre-Requisites
CHM-114 with a grade of 2.0 or better, CHM-116 with a grade of 2.0 or better, MTH-212, and PHY-202

CHM-353. Physical Chemistry: Quantum and Spectroscopy Lab

Credits: 1

Laboratory experiments are performed in order to reinforce concepts in CHM-351. Bench as well as computational experiments will explore the photoelectric effect, resonance states of a particle in a one-dimensional box, applications of molecular orbital theory, and molecular spectroscopy. Three hours per week.

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Co-Requisites

CHM-354. Physical Chemistry: Kinetics and Thermodynamics Lab

Credits: 1

Laboratory experiments are performed in order to reinforce concepts in CHM-352. Bench as well as computational experiments explore calorimetry, phase equilibria, colligative properties, kinetics, and applications of the Monte Carlo method to chemical kinetics. One three-hour lab per week.

Co-Requisites

CHM-355. Physical Chemistry for Life Sciences

Credits: 3

An introduction to traditional physical chemistry topics, including additional topics related to life sciences. Laws of thermodynamics, equilibria, kinetics, and spectroscopy will be discussed in terms of their application to life sciences. Three hours of lecture per week.

Pre-Requisites
CHM-114 with a grade of 2.0 or better, CHM-116 with a grade of 2.0 or better, MTH-212 and PHY-202
Co-Requisites

CHM-357. Physical Chemistry for Life Sciences Lab

Credits: 1

The laboratory experiments emphasize concepts presented in CHM-355. Course includes experimental work, analysis of a research article, and computer simulations relevant to life sciences. One three-hour laboratory pre week.

Co-Requisites

CHM-361. Biochemistry: Structure and Function

Credits: 3

This course presents a study of the physical and chemical properties of proteins, nucleic acid, fatty acids, and carbohydrates, emphasizing the relationship between the chemical structure and the biological function. The course includes the physical methods of biochemistry, enzyme kinetics, bioenergetics, and nucleic acid transcription and translation. Three hours of lecture per week.

Pre-Requisites
CHM-232 with a grade of 2.0 or better

CHM-362. Biochemistry: Metabolism

Credits: 3

This course presents a study of the catabolism and anabolism of carbohydrates, fatty acids, and amino acids. The course emphasizes the regulation and integration of major metabolic pathways, including glycolysis, the Krebs cycle, electron transport, gluconeogenesis, pentose phosphate pathway, fatty acid metabolism, and amino acid metabolism. Three hours of lecture per week.

Pre-Requisites
CHM-232 with a grade of 2.0 or better

CHM-363. Biochemistry Laboratory

Credits: 1

Laboratory experiments, which emphasize biochemical techniques used in isolation and characterization of macromolecules. Included in the course are various chromatographic techniques, electrophoresis, spectrophotometry, and classic biochemical methods. Laboratory, three hours a week. 

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Pre-Requisites

Prerequisite or Corequisite: CHM-361 or permission of instructor.

CHM-365. Medical Biochemistry

Credits: 4

Introduction to basic biochemistry concepts, focusing on the structure and function of vitamins, proteins, and lipids, as well as bioenergetics and major catabolic pathways. The catabolism of carbohydrates, fats and amino acids, including reactions and regulation, will be discussed. Common metabolic pathways of drugs, enzyme induction and metabolism down regulation will also be presented. Four hours of lecture per week.  Cross-listed with PHA-365 and BEGR-465.

Pre-Requisites
CHM-232 or CHM-235 with a grade of 2.0 or better, or permission of the instructor

CHM-370. CHM 371,CHM 372 Integrated Laboratories I, II, III

Credits: 1-2 each

Laboratory experiments related to the five major areas of chemistry. Labs will be chosen in order that students might demonstrate proficiency in each of the required areas. Labs will include synthesis, isolation, and characterization of chemical compounds, spectroscopy, kinetics, calorimetry, chromatography, electrophoresis, and other chemical and biochemical methods. Three hours of laboratory per week per credit hour.

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Pre-Requisites
CHM-232 with a grade of 2.0 or better, CHM-234 with a grade of 2.0 or better and CHM-341 with a grade of 2.0 or better


CHM-390. Junior Seminar

Credits: 1

CHM-390 is a one-hour course offered during the spring semester. It is designed to prepare chemistry and biochemistry majors for their careers after graduation and for their capstone research projects, undertaken in the fourth year. The course will cover topics such as résumé preparation, communication of scientific information, internships, job searches, and preparation for graduate school. Students will prepare a topical literature review on their chosen project in conjunction with their selection of a research advisor.

Pre-Requisites
45 hours of service to the Chemistry Department. Requirements; Junior standing and declared major in Chemistry or Biochemistry.

CHM-391. Senior Research I

Credits: 2

Students will plan and execute a chemistry research project under the direction of a faculty member. It is expected that this will be a laboratory research project. Students will also learn how to search the chemical literature. Students are required to attend weekly Department seminars and present at least one seminar. Requirements: Senior standing in a Chemistry curriculum.

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Pre-Requisites
CHM-352 with a grade of 2.0 or better or CHM-355 with a grade of 2.0 or better

CHM-392. Senior Research II

Credits: 2

Students will carry out a chemistry research project under the direction of a faculty member. It is expected that the project will be a laboratory research project. The project must culminate in a written report and the results must be presented at a Department poster event. Students are also required to attend any seminars hosted by the Department.  Six hours of laboratory / research work per week.

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Pre-Requisites
CHM-391 with a grade of 2.0 or better

CHM-395. Independent Research

Credits: 1-3

Independent study and research for advanced students in the field of the major under the direction of a staff member. A research paper is required. 

Requirements: permission of the instructor.

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CHM-396. Independent Research

Credits: 1-3

Independent study and research for advanced students in the field of the major under the direction of a staff member. A research paper is required. 

Requirements: permission of the instructor.

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CHM-398. Topics

Credits: 1-3

A study of topics of special interest, such as advanced physical chemistry, advanced analytical chemistry, advanced organic chemistry, surface and colloid chemistry, nuclear chemistry, chemical kinetics, polymer chemistry, or spectroscopy.

Pre-Requisites
Will vary according to the specific topics course.

CHM-399. Cooperative Education

Credits: 1-6

Professional cooperative education placement in a private or public organization related to the student’s academic objectives and career goals. In addition to their work experience, students are required to submit weekly reaction papers and an academic project to a Faculty Coordinator in the student’s discipline. See the Cooperative Education section of this bulletin for placement procedures.Requirements: Sophomore standing; minimum 2.0 cumulative GPA; consent of the academic advisor; and approval of placement by the department chairperson. Students without the indicated prerequisites for 200 and 300-level chemistry courses may enroll after written permission of the instructor has been approved by the department chair.


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