At WIESS, undergraduates collaborating with faculty members carry out most research. Each faculty member associated with the Institute has a separate laboratory. Research projects include real-time monitoring of water quality in the Susquehanna River, the influence of environmental factors on the development of Crohn's disease, methods to restore abandoned mine lands and mitigate the effects of acid mine drainage, the effect of endocrine disruptors on development of crustaceans, and the effects of small mammals on dispersal and establishment of oaks.
WIESS research is funded by the National Science Foundation, the National Institutes of Health, the Environmental Protection Agency, and the US Department of Agriculture as well as state and local agencies. Results are published in national and international scientific journals and are also disseminated through regional and national scientific meetings.