Wilkes University

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Witczak

Dr.  Zbigniew  J.  Witczak

Professor/Chair
Pharmaceutical Sciences
 
Professor and Chair, Department of Pharmaceutical Sciences.  
Ph.D. 1979, Medical University, Faculty of Pharmacy, Lodz, Poland
 
Zbigniew J. Witczak obtained his Ph.D. from Medical University of Lodz, Faculty of Pharmacy. Lodz, Poland. After postdoctoral work with Roy L. Whistler at Purdue University he briefly worked in industry (A. E. Staley) and joined in 1990 Faculty in School of Pharmacy at University of Connecticut. He moved to Wilkes University, Nesbitt School of Pharmacy in 2000 where he is Full Professor. He has published over hundred research papers and book chapters, edited six books and holds six patents in the fields of carbohydrate medicinal and biological chemistry.

In 1997 he was awarded John S. Burlew Award from the ACS Connecticut Valley Section. In 2000 he was awarded the Melville L. Wolfrom Award from the ACS Division of Carbohydrate Chemistry for his outstanding research contribution to carbohydrate chemistry and service to the division. He is US Representative to the International Carbohydrate Organization.

His research interests are in the area of thio sugars and carbohydrate synthons including Levoglucosenone and L-Arabinose as template for carbohydrate based therapeutics. He is a member of several editorial boards of renowned chemical and pharmaceutical journals. In 2011 he was selected as one of the 2011 ACS Fellows.

 
  • Mycalamides, Pederin and Psymberin as Natural Carbohydrates and Potential Antitumor Agents: Past and Future Perspectives. Z. J. Witczak, R. M. Rampulla, A. Bommareddy, Mini Review in Medicinal Chemistry12, (14), 1520-1532, 2012. 3 Citations, IF2.921
  • Thio-click Approach to Glycomimetics. Z. J. Witczak, Phosporus, Sulfur & Silicon and the related Elements, 188, 237-244, 2012. IF 0.716
  • Strategies of Coupling Molecular Units when later Decoupling is needed. R. Bielski, Z. J. Witczak, Chem. Rev113, 2205-2243, 2013.DOI: 10.1021/cr200338q. 1 Citation, IF 41.298
  • Prostate cancer chemoprevention by major dietary phytochemicals: A minireview”. A. Bommareddy*, W. Eggleston, S. Prelewicz, A. Antal,Z. J. Witczak, D. F. McCune and A. L. VanWert, Anticancer Res., 33, 4163-41742013. 1 citation, IF 1.725
  • Click Chemistry in Glycoscience: New Development and Strategies, Edited by Z. J. Witczak and R. Bielski, John Wiley & Sons, New York, 2013
  •  A Potential CARB-pharmacophore for antineoplastic activity. Part I. Z. J. Witczak, T. Poplawski A. Czubatka, J. Sarnik, P. Tokarz, A. L. VanWert, R. Bielski, Bioorganic &Med. Chem. Lett., 2014, 241752-1757, IF 2.338.
  • Paradigm and Advantage of Carbohydrate Click Chemistry Strategy for Future Decoupling” R. Bielski, Z. J. Witczak, in“Click Chemistry in Glycoscience: New Developments and Strategies” Edited by Z. J. Witczak, R. Bielski, John Wiley & Sons, New York, pg. 3-30, 2013.
  • Thio-Click Chemistry Overview and Perspectives” Z. J. Witczak, in“Click Chemistry in Glycoscience: New Developments and Strategies” Edited by Z. J. Witczak, R. Bielski, John Wiley & Sons, New York, pg. 33-43, 2013.
  • New Developments in the synthesis of deoxy- and branched-chain sugars” R. Bielski, Z. J. Witczak, Current Org Chem. 2014, 18, (14), 1897-1912.
  • Thio-sugar motif of functional CARB-pharmacophore for antineoplastic activity. Part II. Z. J. Witczak, J. Sarnik, A. Czubatka, E. Forma, T. Poplawski, Bioorganic &Med. Chem. Lett., 2014, 24, 5606-5611.
  • A novel carbohydrate derived compound FCP5 causes DNA strand breaks and oxidative modifications of DNA bases in cancer cells”.  A. Czubatka, J. Sarnik, D. Lucent,J. Blasiak, Z. J. Witczak, T. Poplawski, Chemico-Biological Interaction., 2015227, 77-88 
  • Pederin, Psymberin and the Structurally Related Mycalamides: Synthetic Aspects and Biological Activities” Z. J. Witczak, A. Bommareddy, A. L. VanWert, in “Handbook of Anticancer Drugs from Marine Origin” Edited by Se-Kwon Kim, Springer, Heidelberg, pg. 683-700, 2015.
  • Domino and Rearrangement Reaction in Carbohydrate Chemistry: New Development and Strategies in Glycoscience, Edited by Z. J. Witczak and R. Bielski, John Wiley & Sons, New York, 2016
  • Introduction to Rearrangement Reactions in Carbohydrate Chemistry, Z. J. Witczak, R. Bielski, in “Domino and Rearrangement Reactions in Carbohydrate Chemistry: New Developments and Strategies in Glycoscience” Edited by Z. J. Witczak, R. Bielski, John Wiley & Sons, New York, pg. 209-218, 2016.
  • Novel Levoglucosenone derivatives Z. J. Witczak, R. Bielski, in “Domino and Rearrangement Reactions in Carbohydrate Chemistry: New Developments and Strategies in Glycoscience” Edited by Z. J. Witczak, R. Bielski, John Wiley & Sons, New York, pg. 240-247, 2016.
  • Organosulfur Compounds Derived from Allium Vegetables in Cancer Prevention and Therapy” A. Bommareddy, A. L. VanWert, D.F. McCune, S. L. Brozena, Z. J. Witczak, S.V. Singh in “Critical Dietary Factors in Cancer Chemoprevention” Edited by M. F. Ullah, A. Ahmad, Springer, Heidelberg, pg. 111-153, 2016.
  • Hetero Oxa-Claisen Rearrangement: Perspective on New Synthetic Pathways and Structures   by R. Bielski,*, Z.J. Witczak,* and D. Lucent, Current Organic Synthesis2016, 13, 750-760.
  • Recent examples of novel synthetic approaches to diverse amino sugars, by Z.J. Witczak, R. Bielski - Carbohydrate Chemistry: 2017, 42, 344-367
  • The oxidative induction of DNA lesions in cancer cells by 5-thio-D-glucose and 6-thio-D-fructopyranose and their genotoxic effects. Part 3. J. Sarnik, A. Czubatka-Bieńkowska, A. Macieja, Z. J. Witczak, T. Poplawski, Bioorganic & Med. Chem. Lett., 2017, 27, 1210-1214.
  • The induction of oxidative stress in cervix carcinoma by levoglucosenone derived 4-S-salicyl derivative and (1-4)-S-thiodisaccharides. Part 4. J. Sarnik, A. Czubatka-Bieńkowska, A. Macieja, R. Bielski, Z. J. Witczak, T. Poplawski, Bioorganic & Med. Chem. Lett., 2017, 27, 1215-1219.
  • “Evaluation of the Mycobactericidal Effect of Thio-functionalized Carbohydrate Derivatives”. M. Korycka, Machala, A. Brzostek, B. Dziadek, M. Kawka, T. Poplawski, Z. J. Witczak, J. Dziadek, Molecules, 2017, 22, 812-827.
  • “Thio-functionalized thiosemicarbazones and their evaluation of anticancer activity”. A. Czubatka-Bienkowska, J. Sarnik, A. Macieja, G. Galita, Z. J. Witczak, T. Poplawski, Bioorganic & Med. Chem. Lett., 2017, 27, 2713-2720.
  • "Concise and Efficient Synthesis of Exo-cyclic Carbohydate Enones. Aldol Condensation of Dihydrolevoglucosenone with Five membered Aromatic Aldehydes. Part 1." Z.J. Witczak, R. Bielski, D.E. Mencer, Tetrahedron Letters2017, 58. 4069-4072
  • “Recognition of Thiols in Coupling Reactions to Organic and Carbohydrate Acceptors” Z. J. Witczak, R. Bielski, in “Strategies for Coupling and Decoupling Molecular Units in Glycoscience” Edited by Z. J. Witczak, R. Bielski, Springer, Heidelberg, pg. 155-166, 2017.
  • “Example of Sacrificial Unit Using Two Different Click Reactions in Coupling and Decoupling (CAD) Chemistry” R. Bielski, Z. J. Witczak, D. Mencer in “Strategies for coupling and decoupling Molecular units in Glycoscience” Edited by Z. J. Witczak, R. Bielski, Springer, Heidelberg, pg. 299-308, 2017.
  • Chemistry and functionalization of carbohydrate synthons: Levoglucosenone & isolevoglucosenone
  • Chemistry and medicinal chemistry of thio-sugars
  • Chemistry of natural products
  • Click and thio-click chemistry and domino reaction.
  • 2011 ACS Fellow, AmericanChemical Society, Washington DC.
  • 2006 Elected US Representative to the International Carbohydrate Organization.
  • 2007 President of USA ACCARB
  • 2003 Elected Teacher of the Year , Nesbitt School of Pharmacy, Wilkes University.
  • 2000 Melville L. Wolfrom Award, of the Division of Carbohydrate Chemistry of the ACS.
  • 1997 John S. Burlew , Connecticut Valley Section Award of American Chemical Society.
  • 1996 Elected Teacher of the Year , School of Pharmacy, University of Connecticut.
  • 1995 2nd Prize-Paper presentation at 1st International Glupor Meeting, Lisbon, Portugal.

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